Box of Spiders 
Effects
- (Removed in Repentance) Spawns 1-4 Blue Spiders.
- (Added in Afterbirth †) This item belongs to the Spider Baby set. Collecting three items from this set will transform Isaac into a humanoid spider.
Notes
- (Removed in Repentance) Blue Spiders deal 2.5x Isaac's damage.
- (Added in Repentance) Blue Spiders deal 2x Isaac's damage.
Interactions
- (Added in Repentance)
Book of Virtues: Spawns wisps instead of spiders, in the outer ring. Wisps summon Blue Spiders when destroyed. One wisp contains one Blue Spider.