Bursting Sack 
Effect
- Certain spider enemies no longer target or deal contact damage to Isaac, nor actively spawn other enemies. Spiders that are spawned from enemies that are not affected by Bursting Sack will also remain neutral.
- Affected spider enemies that deal no damage to Isaac whatsoever include: (Baby Long Legs) Baby Long Legs, (Big Spider) Big Spider, (Crazy Long Legs) Crazy Long Legs, (Level 2 Spider) Level 2 Spider, (Small Baby Long Legs) Small Baby Long Legs, (Small Crazy Long Legs) Small Crazy Long Legs and (Spider) Spider.
- (Removed in Repentance) Unaffected spider enemies include: (Blind Creep) Blind Creep, (Blister) Blister, (Rage Creep) Rage Creep, (Ragling) Ragling, (Rag Man's Ragling) Rag Man's Ragling, (The Thing) The Thing, (Trite) Trite and (Wall Creep) Wall Creep.
- (Added in Repentance) Affected enemies that deal no contact damage but can still damage Isaac through other methods include: (Blind Creep) Blind Creep, (Blister) Blister, (Migraine) Migraine, (Rage Creep) Rage Creep, (Ragling) Ragling, (Rag Man's Ragling) Rag Man's Ragling, (Soy Creep) Soy Creep, (Tainted Soy Creep) Tainted Soy Creep, (The Thing) The Thing, (Ticking Spider) Ticking Spider, and (Wall Creep) Wall Creep.
- Except for Ticking Spiders, Migraines, and Blind Creeps, all other spiders will still uselessly try to target Isaac for contact damage.
- (Added in Repentance) (Coal Spider) Coal Spiders aren't aggressive to Isaac, but will still deal contact damage.
- (Added in Repentance) (Twitchy) Twitchies are not counted as "spider" enemies and are unaffected by this item.
- (Added in Repentance) This item belongs to the (Spider Baby) Spider Baby. Collecting three items from this set will transform Isaac into a humanoid spider.
Notes