Chaos 
Effects
- Drops 1-6 random pickups around Isaac.
- Causes items to be chosen from random item pools.
Notes
- When playing Greed mode, items that are available only in the normal game will still not appear despite Chaos; the modes' different item pools stay separate.
- As the item does not mix or combine item pools, it is possible to deplete smaller item pools and end up with
Breakfast before all items in the game have been taken.
- Thus, if Chaos tries to pull from an item pool that is already depleted, it will not pull from a different pool and instead give Isaac Breakfast.
- As many Greed Mode item pools are small, Chaos tends to result in Breakfast more often during Greed mode.
- (Removed in Repentance) Chaos will draw items even from item pools that are not used in the game, but defined in the game's files. The unused pools are
bossrush containing nearly all bomb related items, challenge with a smaller selection of bomb items and dungeon containing several Mom related items and food items.
- (Removed in Repentance) Since all item pools have the same probability of being selected, bomb-related items are much more common due to the Bomb Bum,
bossrush and challenge item pools.
- (Added in Repentance) Each pool has a weight based on the number of items in the pool. Items from large pools such as Treasure Room, Shop, and Boss are very likely, while items from small pools like Bomb Bum and Planetarium are more rare.
- If an item outside of the Devil Room pool appears as a Devil Deal, it will always cost 1 Red Heart Container (or 3 Soul Hearts should Isaac have no Red Hearts).
- (Added in Afterbirth †) Bosses defeated in (The Void) The Void drop items as if Chaos was active. Re-rolling the items uses the Boss Room pool as normal.
Interactions
Cube of Meat after defeating one of The Harbingers as a floor boss, or 
The Small Rock after breaking a Tinted Rock.
Sacrificial Altar: Ignores Chaos's effect and always picks items from the normal Devil Room pool, even on Greed Mode.