Curse of the Tower

Effect

Upon taking damage, spawns six Troll Bombs around the room, similar to the effect of (XVI - The Tower) XVI - The Tower.

Despite appearing as Troll Bombs, the bombs are mechanically identical to player-placed bombs and will benefit from Isaac's bomb-enhancing items.
These bombs hurt the player as well as enemies.
Taking damage from the Troll Bombs spawned by Curse of the Tower or any other type of bomb, including Isaac's bombs, will not re-activate the effect.
(Removed in Repentance) Picking up this item will make all health transactions more difficult. Devil Beggars and Blood Donation Machines will be almost impossible to use because they will very likely be destroyed by bombs.
- (Added in Repentance) Taking damage from Devil Beggars and Blood Donation Machines does not trigger the effect.
The bombs prefer to spawn near the center of the room.
The 6 Troll Bombs are difficult to dodge in small rooms.

Pyromaniac: Troll Bombs will heal Isaac instead, allowing for essentially infinite health with proper usage.
- (Added in Repentance) Due to Pyromaniac being weakened to healing half a heart per explosion in Repentance, this synergy requires The Wafer to continue being effective past Chapter 3/Chapter 3.5.
The Polaroid: If Isaac is damaged when he has half a red heart or no red hearts, the shield will activate and protect him from the Troll Bombs.
Remote Detonator: The Troll Bombs generated will not explode until Remote Detonator is activated, unlike regular Troll Bombs.
(Safety Scissors) Safety Scissors: The Troll Bombs generated will be converted into bomb pickups rather than exploding.