E. Coli

Effects

Enemies that touch Isaac are transformed into poop.
(Added in Afterbirth) This item belongs to the Oh Crap set. Collecting three items from this set will transform Isaac into a walking pile of poop.

Bosses cannot be turned into poop.
Poop created by this item is not grid-aligned, and flashes red when hit, similar to damaging monsters.
- (Added in Afterbirth †) Poops produced by E. Coli crumble upon being attacked, identically to regular poops.
If you touch the middle section of a Grub with E. Coli, it will then split and become two heads (rather than destroying and spawning Maggots).
Mullibooms can be turned into poop without taking damage.
The poops vanish if the room is left and then returned to.
(Added in Afterbirth / Removed in Repentance) Poops created by E. Coli do not heal Isaac when he has the Oh Crap transformation.
(Added in Repentance) Poops created by E. Coli heal Isaac when he has the Oh Crap transformation.

Isaac's Heart: Isaac can turn enemies into poop without taking damage.
Midas' Touch: Enemies touched are turned into Golden Poop.
Unicorn Stump: Provides invincibility during which enemies can be touched.
(Added in Repentance) Lodestone: If an enemy is hit by a lodestone tear perfectly simultaneously with it being turned into poop, the resulting poop will be tinted black and have a lodestone aura that sucks in enemies. This poop will return to normal after a few seconds.
(Added in Repentance) (Tainted Forgotten) Tainted Forgotten: The body will turn enemies into poop on contact.

(Added in Afterbirth)(Brown Cap) Brown Cap: The generated poops are affected and will explode when destroyed.
(Added in Afterbirth †) Hallowed Ground: The generated poops cannot be white.
(Added in Afterbirth †)(Meconium) Meconium: The generated poops cannot be black.
(Added in Afterbirth) Serpent's Kiss / The Virus: The poops won't drop Black Hearts, negating the touch effect from these items on non-bosses.