Mama Mega!

Effects

• Destroys all obstacles in the current room and deals 200 damage to every enemy (including Bosses). This effect also applies to every room for the remainder of the floor.
  • (Added in Repentance) Also destroys all Machines, Beggars, Shopkeepers, and Fire Places.
  • (Added in Repentance) Also destroys all obstacles in rooms that have already been cleared.
  • (Added in Repentance) Will cause an explosion on Donation Machines as well, reducing donated coin count.
• Opens all (Secret Room) Secret Room and (Super Secret Room) Super Secret Room doors on the current floor.

Notes

• Mama Mega! opens the paths to (Boss Rush) Boss Rush and the (???) ??? even after the time limits expire.
  • The Boss does not need to be defeated before entering these doors.
  • It will also open the Boss Rush / (???) ??? entrance room door if it is activated after Mom or Mom's Heart/It Lives! has already been defeated.
  • Leaving the (Boss Room) Boss Room (via teleport or entering a (Devil Room) Devil Room/(Angel Room) Angel Room) will close the doors.
  • Leaving the (Boss Rush) Boss Rush room or (???) ??? entrance room will also close the doors.
  • (Added in Repentance) Does not open a path to (???) ??? if used in the room on the other side of the flesh door in (Mausoleum) Mausoleum / (Gehenna) Gehenna II.
• Entering a room with an angel statue while the effect is active automatically initiates a fight with an Angel.
• Does not kill Lil' Haunts and other enemies that are immune to damage while entering the room.
• If used before the Ultra Greed fight begins, it will deal no damage to Ultra Greed, as he is invulnerable for the first few seconds upon first entering his room. However, it will still break obstacles as usual.
• When used in Greed mode, it will only activate once for the main room (as opposed to once per wave, in a similar fashion to a standard run). Therefore, its damage potential is maximized if used after all the monster waves have spawned for the current floor.
• Does not open the door to Mega Satan in (Dark Room) Dark Room or (Chest) Chest.
• (Added in Repentance) If used in (Downpour) Downpour / (Dross) Dross II, the entrance to the Mirrored World will be destroyed, making it inaccessible.
  • If used in the Mirrored World, it will destroy the exit, which, on top of making it impossible to leave, will then cause Isaac to take damage and die.
  • This can be avoided by entering and immediately leaving the room before the shockwave reaches the mirror.
• (Added in Repentance) Does not open the flesh door at the end of (Mausoleum) Mausoleum / (Gehenna) Gehenna II.

Synergies

• (Added in Repentance) Book of Virtues: Summons 8 wisps in the middle ring on use. The wisps summon Golden Troll Bombs when destroyed.
• (Added in Repentance)(Broken Padlock) Broken Padlock: Mama Mega!'s blast will also open locks.
• (Golden Bomb) Golden Bomb: While holding a golden bomb, Mama Mega! can be used once on that floor without consuming it but will remove the golden bomb from Isaac's consumables (using it a second time consumes it as normal). It may be used again for free on another floor if yet another golden bomb is collected, and so on.

Interactions

• Car Battery: No effect.
• (Removed in Repentance) Void: Can't be consumed by Void.
  • (Added in Repentance) If consumed by Void, the Mama Mega! effect will be activated once only, the next time Void is activated.
• (Removed in Repentance)(? Card) ? Card: Mama Mega! will be activated and consumed.
  • (Added in Repentance) Mama Mega!'s effect can be activated through the card without consuming the actual item.