Starter Deck

Effects

Allows Isaac to carry two cards or runes at once. Cycle through cards by pressing the Control key (PC), R2 (PlayStation), RT (Xbox), or ZR (Switch, 3DS).
Replaces all pills with cards. Pills already on the ground will be converted to cards or runes upon picking up Starter Deck.
Spawns a random card.
- (Added in Repentance) Runes, soul stones, and other card-like consumables are also possible.

When picking up Starter Deck in a shop that has a pill for purchase, the pill can still be purchased and used. If the pill is dropped, it will be turned into a card.
Picking up 2 Starter Decks won't allow you to carry 3 cards at once.

(Added in Afterbirth †) Acid Baby: Spawns cards or runes instead of pills. Using cards or runes will not trigger the room-wide poisoning effect.
(Removed in Repentance) Caffeine Pill: A pill drops normally, but if it is picked up and dropped, or left on the ground while visiting other rooms, it becomes a card.
Little Baggy: Overrides the effect of Little Baggy (switch from receiving only pills to only cards).
- (Added in Repentance) Having both items allow both cards and pills to appear again.
- Picking up Little Baggy while already holding Starter Deck will turn any held cards or runes into pills for one time.
Mom's Bottle of Pills: Gives a card instead of a pill, essentially becoming equivalent to a Deck of Cards.
(Added in Repentance)(XIV - Temperance?) XIV - Temperance?: Forces Isaac to eat pills even with Starter Deck.