Tammy's Head 
Effects
- Shoots 10 tears in a circle around Isaac.
- The tears retain the Shot Speed and special effects (such as poison) of Isaac's tears.
- Each tear will do Isaac's current damage and a flat +25 damage bonus on top.
Synergies
- (Azazel) Azazel /
Brimstone: Isaac will fire Brimstone lasers in all directions. (Removed in Repentance) Each laser is given bonus damage.
- (Added in Repentance)
Book of Virtues: Spawns pale wisps in the outer ring. The wisps' tears deal 1.5 damage, but fire twice as fast as standard wisps. Tears are inaccurate and fire in a spread.
- (Added in Afterbirth)
Car Battery: Shoots 20 tears in a circle around Isaac.
Chocolate Milk: The size and damage of tears shot depends on how far Chocolate Milk is charged.
- (Tainted Azazel) Tainted Azazel: Although Tainted Azazel's Brimstone beams do not have a damage bonus, they also do not have the normal damage penalty and still deal double damage to enemies that have been sneezed on.
Interactions
Dr. Fetus /
Ipecac: Tears are replaced by bombs or exploding shots, which may result in self-damage.
Epic Fetus: Fires only normal tears.
- (Added in Repentance)
Eye of the Occult: The tears quickly lose their outward momentum and can now be controlled all at once, making it easy to make the tears hit enemies.
Mom's Knife: The tears are replaced with knives that deal double Isaac's damage, but move very quickly, have a small hitbox, and don't return to Isaac.
- (Added in Repentance)
Trisagion: Trisagion blasts, like Brimstone beams, do not get a damage bonus.