The Left Hand

Effects

(Removed in Repentance) The effect includes Chests already spawned. Entering a room that previously contained other types of Chests while holding The Left Hand will turn them into Red Chests permanently.
- (Added in Repentance) Chests that have already spawned are not converted into Red Chests.
It is advised to drop The Left Hand (by holding either CTRL key for few seconds, holding R2 or RT for 3 seconds on PS4 and Vita and Xbox One, respectively, or holding ZR on the New Nintendo 3DS / Nintendo Switch for a few seconds) before entering (Chest) Chest, as non-Red Chests always contain item pedestals on this floor, especially the 4 located in the starting room.
- (Removed in Repentance) Isaac may prefer Red Chests for their possible Soul Hearts or Red Chest items, at the expense of guaranteed items.
- (Added in Repentance) Golden Chests converted in (Chest) Chest's starting room will contain Devil Deals, potentially allowing for more powerful items, but at the cost of Hearts.
  - Red Chests found past the starting rooms of either (Chest) Chest or (Dark Room) Dark Room will contain regular Red Chest drops. Dropping the trinket before leaving the starting room is advised.
(Added in Repentance) Stone Chests are affected by The Left Hand. Old Chests and Mega Chests are not affected.