Cursed Skull

Effects

If Isaac has less than one full Red Heart after taking damage, he will be immediately teleported to a random room.
- (Added in Afterbirth †) The teleportation happens only at half a heart or less left, regardless of health type. Empty Bone Hearts are not counted as health even if they can absorb a hit.

(Scapular) Scapular: Provided Scapular can always trigger, grants effective immortality, as the soul heart is always given before the teleport takes place.
- +(The Wafer) The Wafer: Grants true immortality, plus one hit on the soul heart, allowing the player to get hit once before teleporting.

Does not affect (The Lost) The Lost, as being hit with (Holy Mantle) Holy Mantle does not count as taking damage.
- It will effect Isaac with Spirit Shackles, teleporting the player out of the room and restoring the Holy Mantle charge.
It is not recommended to have this item equipped during a boss fight as the boss's health will be restored to 100% if the player is teleported out of the room and returns, placing the player at a disadvantage unless they have acquired a (Placenta) Placenta.