Empty Vessel

Effects

When Isaac has no Red Hearts:
- Grants flight.
- Every 40 seconds since activation or pickup, when the seconds on the timer hit 00, 20, or 40, while in a room with enemies, a shield triggers, nullifying all types of damage for 10 seconds.
Grants 2 Black Hearts on pickup.

Does not affect (Keeper) Keeper/ (Tainted Keeper) Tainted Keeper.
(Removed in Repentance)This item is difficult to use for anyone with red health, as it is impossible to have no red hearts without removing all heart containers (such as through Devil deals). It is best used by characters that cannot gain red health at all, such as (???) ???.
(Added in Repentance)Characters can now deplete their red health fully through sources like Blood Donation Machines while having other hearts like soul hearts. As a result, this item is usable for a wider amount of characters, and has synergies with characters who prefer to have no red health (such as (Eve) Eve).

(Added in Afterbirth †) Brittle Bones: The empty bone hearts will trigger Empty Vessel.
Gnawed Leaf: If the player has no Red Hearts, they can stand still and wait for the shield to activate, allowing the player to deal damage without leaving invulnerability.