Forget Me Now 
Effects
- On use, the current floor will be completely re-generated and Forget Me Now will be removed from Isaac's inventory.
- Isaac will restart the level as if he had entered a new floor.
Notes
- The re-generated floor will count as the same floor number as the one Isaac used Forget Me Now in.
- If a (Devil Room) Devil Room / (Angel Room) Angel Room is not encountered after defeating the boss of the re-generated floor, the multiplier tied to the number of floors since the last Devil/Angel Room affecting the spawn chance will not change.
- (Added in Repentance) If the first possible (Devil Room) Devil Room is encountered, the 100% chance for the next deal to be an angel chance is preserved upon regenerating the floor.
- If a Devil/Angel Room is encountered before regenerating the floor, the multiplier will become x0.25 upon regenerating the floor.
- Any items earned before using the re-generation effect will remain in Isaac's inventory.
- If used on the (Depths) Depths / (Necropolis) Necropolis / (Dank Depths) Dank Depths II after beating Mom, both
The Negative and 
The Polaroid can be obtained in one run. Additionally, two (Boss Rush) Boss Rushes can be entered as long as the total playtime of the run stays under 20 minutes.
- (Added in Repentance) If used on (Downpour) Downpour / (Dross) Dross II after collecting
Knife Piece 1, a second Knife Piece 1 will spawn in the mirrored world's (Treasure Room) Treasure Room, which can be rerolled into a random item from the Treasure Room (Item Pool).
- If used on (Chest) Chest or (Dark Room) Dark Room when the door to Mega Satan has been opened, the golden key will not re-open the door and you will be unable to fight him.
- If used on an XL floor, the merged chapter can be re-generated as two separate floors instead.
- (Challenge Room) Challenge Rooms and (Boss Challenge Room) Boss Challenge Rooms will have the same rewards and enemy waves as the Challenge Room in the previous iteration of the floor.
- (Added in Repentance) If left in a Treasure or Boss Room and then returned to during the Ascent, the Forget Me Now item will return to the room it was left each time it is used, allowing the floor to be repeated indefinitely.
- This can be useful in conjunction with (Added in Repentance)
The Stairway, as it allows for unlimited Angel Shops to be visited.
- Upon reentry, items, pickups, and trinkets left in treasure and boss room after using Forget Me Now will be removed and not converted into cracked keys.
- If used in Floor 1, the chance of Devil/Angel room is still 0%.
Synergies
- (Added in Repentance)
Book of Virtues: Spawns a wisp in the middle ring with infinite health. The wisp only lasts for the floor Forget Me Now created.