The Negative

Effects

• If the character has half a red heart or no red hearts after taking damage, it triggers The Necronomicon effect, damaging all enemies in the room.
• Allows entrance into the (Dark Room) Dark Room after beating Satan in (Sheol) Sheol by touching the chest.
• (Added in Repentance) +1 damage.
• (Added in Repentance) Opens A Strange Door in (Depths) Depths II and its variants that leads to (Mausoleum) Mausoleum/(Gehenna) Gehenna II.
  • Unlike with the Dark Room entrance, The Negative gets consumed by the door and vanishes from Isaac's inventory.

Notes

• This item is a guaranteed drop from Mom alongside The Polaroid, provided they are unlocked. However, they are mutually exclusive: Once one of them is picked up, the other one will disappear.
  • With the use of a teleportation item and either a 5 pip Dice Room or a Forget Me Now, both The Polaroid and The Negative or multiple copies of The Polaroid or The Negative can be obtained.
  • With (Added in Repentance) (Jacob and Esau) Jacob and Esau, proper alignment of both characters can enable picking up both The Polaroid and The Negative.
• The Negative always triggers when taking damage as characters who lack heart containers, such as (Azazel) Azazel and (Tainted Azazel) Tainted Azazel (by default), (???) ??? and (Tainted ???) Tainted ??? (permanently), (Added in Repentance) (Dark Judas) Dark Judas and (Tainted Judas) Tainted Judas (permanently) (The Forgotten) The Forgotten (only as the soul), (Tainted Forgotten) Tainted Forgotten (permanently), (Dead Tainted Lazarus) Dead Tainted Lazarus(by default), (Tainted Bethany) Tainted Bethany (permanently) or any other character who has chosen to trade away their heart containers in deals with the Devil, Black Markets, or with Guppy's Paw or (Added in Afterbirth †) Potato Peeler.
• The Negative will be the rightmost item after defeating Mom, in case Curse of the Blind is active.
• It is possible to obtain two Negatives by obtaining one as an (Eden) Eden starting item.
• Obtaining multiple copies of The Negative does not cause its effect to stack.
• As with all items crucial to story progress ( Key Piece 1 and Key Piece 2, (Added in Repentance) Knife Piece 1 and (Added in Repentance) Knife Piece 2, (Added in Repentance) Dad's Note, and (Added in Repentance) Dogma), this item has protection from full-run rerolls. It does not, however, share the immunity (Added in Repentance) Dad's Note has to D6-type rerolls and (Added in Afterbirth †) Void.

Synergies

• (Added in Repentance)(A Missing Page) A Missing Page / (Added in Repentance) Missing Page 2: Increases the damage from 40 to 80.
  • A Missing Page + Missing Page 2: The damage increase stacks for a total of 120 damage.