Giant Cell 
Effects
- Whenever Isaac takes damage, he summons a micro-Isaac familiar, known as Minisaac, that chases nearby enemies and attacks on its own.
- Minisaacs deal 1.35 base damage that scales with +0.15 per floor:
damage = 1.35 + 0.15 * (floor - 1)
- Minisaacs shoot 3 tears per second and their tear delay is not affected by Isaac's stats.
- Minisaacs persists between rooms and floors.
- Each Minisaac is spawned with 15 health points that are constantly drained with a rate of 0.4 per second. The draining stops when they reach 0.8 HP.
- They are healed back to full HP whenever Isaac takes damage, even when the familiars cap is reached.
- Enemies can damage Minisaacs by shooting projectiles at them or dealing contact damage.
- Isaac's bomb explosions will also damage the familiars.
- Minisaacs are immune to spikes and lasers.
Notes
- The familiar cap for Giant Cell is 16, after which taking damage will not spawn a new Minisaac.
- Minisaacs will change their skin color based on the character that they were spawned from.
- Certain items that change skin color can also affect the familiars' appearance.
- When playing as (The Forgotten) The Forgotten, the familiars take the style as either The Soul or The Forgotten, depending on who gets hit.
- If the familiar takes the style of The Forgotten, it will also inherit its bone club attack, dealing 8.1 base damage that scales with +0.9 per floor. It will swing its bone club 1.5 times per second.
- Minisaacs for (Tainted Forgotten) Tainted Forgotten will spawn from The Forgotten's body and inherit its skin color but they will shoot regular tears.
- Familiars spawned for (Azazel) Azazel or (Tainted Azazel) Tainted Azazel will not inherit the
Brimstone laser and will fire regular tears.
- If Isaac has any form of flight, the Minisaacs will receive wings and will be able to fly as well.
- Minisaacs spawned before flight was acquired will not get upgraded, unless the flight is acquired by killing Dogma and starting The Beast fight in which case they will get upgraded.
- There's an unused Shadow-like minisaac that looks like it should be spawned from (Dark Judas) Dark Judas, but this isn't the case.
Synergies
BFFS!: Increases damage dealt by the familiars by 40%.
The Common Cold / 
Ipecac: Minisaacs will be colored green but they will not get any benefits nor shoot out poison tears.
Dull Razor: Provides a penalty-free way of spawning Minisaacs and/or healing existing ones.
Sacrificial Altar: Converts all micro-Isaacs into 1 Penny each upon use.
Terra: Makes Minisaacs grey.
Interactions
- Many familiar-modifying items and trinkets do not affect the Minisaacs. These include:
