The D6

Effect

• Upon use, replaces every item in the current room (not pickups or trinkets) with other random items corresponding to the current room's item pool.

Notes

• (Removed in Repentance) The D6 is a special item.
• (Isaac) Isaac starts with this item once it is unlocked.
• Since it re-rolls every item in the room, it can be more efficient to use it in rooms where multiple items are in the same room. For instance:
  • In the (Shop) Shop, when multiple items are available for purchase.
  • In the (Devil Room) Devil Room, when there are multiple deals offered.
  • In the (Boss Room) Boss Room after the Mom fight, where both The Polaroid and The Negative can be rerolled, at the cost of the opportunity to go to the (Chest) Chest/(Dark Room) Dark Room. Once one item is picked up the other will disappear.
  • In the (Boss Rush) Boss Rush Room, where all 4 items can be rerolled at once.
  • When There's Options or (Added in Afterbirth) More Options spawn two items.
• Items from chests can be rerolled.
• When an item pool is exhausted, every item will be rerolled to Breakfast.
• If Isaac runs out of red hearts in the (Devil Room) Devil Room, then rerolls, the prices of the items switch over to soul hearts.
• Using the D6 on an active item yields different rerolls depending on whether you picked up the active item first.
• Using the D6 to reroll items duplicated with (Added in Afterbirth) Diplopia will reroll all the items into different items. The copied item will not be rerolled into the same one as the original item.
• With Sharp Plug and any combination of items that can infinitely regenerate health, the D6 can be used to reroll items indefinitely.
• Be careful when rerolling, as it will replace the item with another item from the current room's item pool. This can be used as an advantage in various ways; for example, after defeating The Fallen, the item will be drawn from the Devil Room item pool, so Isaac can safely roll the item into another from that pool. This behavior can also be an advantage in (Angel Room) Angel Rooms since Key Piece 1 and Key Piece 2 can be rerolled to get a free Angel Room item.

Synergies

• (Added in Repentance) Book of Virtues: Spawns a white wisp in the middle ring. An extra wisp is spawned per item rerolled.

Interactions

• (Added in Afterbirth) Car Battery: Re-rolls twice instantly without any benefits.
• (Added in Repentance)(Soul of Isaac) Soul of Isaac: Using the D6 re-rolls the current item and cancels alternation.