Zodiac 
Effects
- Gives Isaac a random Zodiac item effect that changes each floor.
Notes
- Getting
Capricorn, 
Cancer and 
Libra does not grant coins, bombs, keys or Soul Hearts.
- (Removed in Repentance) Getting
Leo will not change Isaac's size.
- If already in possession of the item given by Zodiac, most have no effect. The only exceptions are Capricorn giving an additional +0.5 damage, and
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Gemini giving another familiar.
- (Added in Repentance) Getting
Virgo does not provide the 
PHD effect for the floor it is obtained. It does grant the chance to trigger a protective shield on taking damage however.