Blister 
Effect
- Increases the knockback of Isaac's tears.
 
Synergies
- (8 Inch Nails) 8 Inch Nails / (Pisces) Pisces: The knockback from Blister is stronger than from the items, and knockback boosts do not stack.
 - (Brimstone) Brimstone: The beam pushes back enemies.
 - (The Ludovico Technique) The Ludovico Technique: The controlled tear gains knockback.
 - (Mom's Knife) Mom's Knife: The knife gains knockback.
 - Piercing tears: Tears can again knock enemies back.
 - (Tech.5) Tech.5 / (Tech X) Tech X / (Technology) Technology / (Technology 2) Technology 2: Pushes the enemies back along the lasers. For Tech X, the direction is counter-clockwise around the ring.
 - (Added in Afterbirth †)(Trisagion) Trisagion: Adds knockback, which can deal devastating damage to enemies caught in the blast.