Tech.5 
Effects
- Grants an unlimited range piercing laser with random rate of fire that does not replace tears.
- The laser has a 1/6 chance to fire every ~0.07 seconds (4 frames), firing at an average rate of 2.5 times per second.
- The laser occasionally fires with the effect of a random item or trinket, including:
Notes
- The damage of the laser scales directly with Isaac's damage.
- Unlike
Technology or 
Technology 2, Isaac can still fire tears from both eyes in addition to firing the laser.
- The laser can be fired independently from tears by slightly tilting the right analog stick, just like shooting familiars.
- (Added in Repentance) Unlike Technology, Tech.5 Lasers do not have momentum, and fire exclusively in the cardinal directions unless Isaac has an item like (Added in Afterbirth †)
Analog Stick, (Added in Repentance)
Eye of the Occult or (Added in Afterbirth)
Marked.
Interactions
- (Added in Repentance)
Anti-Gravity: Creates floating laser balls that will all fire simultaneously when the fire button is released.
Brimstone: Tech.5 does not fire. However, it will still fire when playing as (Azazel) Azazel with his short-ranged Brimstone. Since the laser scales with player damage, this can be a devastating combination.
- (Added in Afterbirth) Tech.5 fires normally while Brimstone laser is charging.
- (Removed in Repentance)
Cricket's Body: Tear delay down as expected, but no benefit from the splash effect.
- (Added in Repentance) Releases a 4-way spread of tears whenever the laser hits a wall or an enemy.
- (Added in Afterbirth) (Lilith) Lilith: No effect, as Lilith is inherently Blindfolded.
The Ludovico Technique: Laser is fired in the same direction that the controlled tear is moving.- (Added in Repentance)
Ipecac: Laser explodes and poisons enemies on contact.
Rubber Cement: Laser will bounce in angle depending on the obstacle hit.
Spoon Bender
Tiny Planet
Mysterious Liquid