D100 
Effects
Upon use, it:
- (Added in Repentance) Duplicates 1 random pickup in the current room (like the
D1). - Rerolls all passive items on Isaac (like the
D4). - Rerolls all pedestal items in the room (like
The D6). - (Added in Repentance) Restarts the room and respawns all enemies (like the
D7). - (Added in Repentance) Rerolls Isaac's damage, tears, range and speed (like the
D8). - (Added in Repentance) Rerolls all monsters in the room (like the
D10). - (Added in Repentance) Rerolls all rocks in the room (like the
D12). - Rerolls all pickups in the room (like the
D20).
Notes
- (Removed in Repentance) D100 is a special item.
- (Removed in Repentance) See the
D4,
The D6, and the
D20 to learn more about the respective individual effects.
Synergies
- (Added in Repentance)
Book of Virtues: Removes all of Isaac's wisps and gives him one random wisp for every two items rerolled. Book of Virtues will not be rerolled in the process.