Fate's Reward 
Effects
- Spawns a familiar that fires tears with the same damage and tear effects as Isaac's tears.
- Fires at half the normal fire rate of a familiar.
- The familiar is not affected by range, only tear height.
Synergies
- (Added in Afterbirth †)
Flat Stone: Familiar's tears will travel very far and then bounce once, traveling up and hitting the nearest wall.
- (Added in Afterbirth †)
Haemolacria: Will fire tears that burst into split tears. Does not affect fire rate.
Ipecac: Will fire explosive tears. Does not affect fire rate.
- (Added in Afterbirth †)
Lachryphagy +
Brimstone: The tears fired by the familiar will eventually explode in a star-like pattern of Brimstone lasers if they don't hit anything.
Interactions
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Following tear modifiers do not affect Fate's Reward, and the familiar will only fire normal tears:
Brimstone
- (Added in Repentance)
C Section
Dr. Fetus
Epic Fetus
The Ludovico Technique
Mom's Knife
Monstro's Lung
Technology
Tech X
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20/20 /
The Inner Eye /
Mutant Spider: Fate's Reward only fires single tears. The items do not affect the fire rate of Fate's Reward.
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Chocolate Milk: Familiar's tears will turn a brown color but can not be charged.
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(Added in Repentance)(Found Soul) Found Soul: While the soul is alive, decreases Fate's Reward damage by 20%.
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(Removed in Repentance)
Marked: Fate's Reward will only fire while the crosshair is being moved, and can only fire in cardinal directions.
- (Added in Repentance) Fate's Reward will aim and fire at the crosshair, wherever it's pointed.
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Soy Milk: Does not affect fire rate, but does affect damage.