Polyphemus

Effects

• Greatly increased damage: ({\textstyle {(Damage+4)\times 2}})
• (Removed in Repentance) Tears down: ({\textstyle {(Delay\times 2.1)+3}})
• (Added in Repentance) Tears fired per second * 0.42.
• If a tear kills an enemy, the tear travels on with any leftover damage.

Notes

• (Removed in Repentance) Polyphemus is a special item.

Synergies

• Dr. Fetus: Increases tear delay, and after the first bomb explodes, a second bomb appears where the first one exploded, doing roughly half the damage of the first.
• The Inner Eye/ Mutant Spider: The tear rate is not lowered further, but the effect on damage becomes a flat +5 bonus instead.
• (Added in Afterbirth †) (The Forgotten) The Forgotten: The Forgotten's bone club becomes massive. It deals very high damage but has a very low swing rate.
• (Added in Repentance) Rock Bottom: Allows Isaac to keep his previous fire rate in addition to the massive damage boost.
• (Added in Repentance) Shard of Glass: The rapidly spawning red tears do full damage.

Interactions

• (Added in Afterbirth †) Haemolacria: The main tear retains the semi-piercing ability and may not burst when hitting a weaker enemy. Split tears do not semi-pierce.
• (Added in Afterbirth †) Lachryphagy: Greatly increases how big the fed tear can grow.
• Lost Contact: Isaac's tears will block enemy shots and continue, but lose 10 damage. If the tear had less than 10 damage left, it disappears.
• Piercing tears: Semi-piercing is replaced by proper piercing, with no loss of damage on any enemy contact.
• Polyphemus: No further effect when multiple copies are acquired.