Redemption

Effects

Upon entering a Devil Room, a white inverted cross will appear above Isaac's head. Taking anything generated by the room (items or consumables) will result in the icon going away.
- Opening Red Chests will also make the icon go away.
  - However, getting an item from a Red Chest will keep the icon.
  - Opening Red Chests that have been spawned after room generation, e.g. as a room clear reward or enemy drop, won't remove the icon.
- Taking A Lump of Coal or Head of Krampus after Krampus fight will keep the icon.
If Isaac goes to the next floor with the icon still above his head, he will gain a soul heart and +1.0 damage.

After Isaac has taken a Devil Deal, while a Confessional or Sacrifice Room would give an Angel Room item, it will instead spawn Redemption. This is the only way Redemption can be naturally generated during a run.
- Other reliable ways includes using Death Certificate, or using Spindown Dice on Spirit Shackles.
- Redemption has a small chance to be a starting item as (Eden) Eden, (Tainted Eden) Tainted Eden, or any character with Eden's Blessing.
- Using Birthright as (Eden) Eden has a small chance to spawn Redemption.
- If Act of Contrition was taken after taking a Devil Deal, Redemption is not guaranteed to spawn.
Picking up items made free through usage of items such as Coupon or a Credit Card will still remove the icon and provide no benefit.
- However picking up free active item and swapping it with one you have will not affect the icon.
Red Treasure Rooms created by (Devil's Crown) Devil's Crown also count as Devil Rooms for the purposes of this item.
Taking pickups dropped by Fire Places will not remove the cross.
Taking items inside the Devil Room spawned by Devil Beggars will not remove the cross.
Taking items from a Black Market will not remove the cross.
Taking the boss's item affected by Satanic Bible will remove the cross.
When playing as (Tainted Lazarus) Tainted Lazarus, the holder must enter the Devil room to trigger the cross; it will not work if you transform inside. The character with the inverted cross must be the one to travel to the next floor.

Glowing Hour Glass: +1 damage given by Redemption will persist after time leap to the upper floor, as well as giving another activated Redemption after time leap. The soul heart given by Redemption will only persist if you time leap to the upper floor before Redemption finishes its animation. This will allow to take the Redemption damage buff and soul hearts several times per floor. However, if you can use Glowing Hour Glass two times in a row, in order to get 2 soul hearts, you'll need to leave the boss room before going down the floor the second time.