IV Bag

Effects

Upon use, causes Isaac to lose half a heart of health (or a full heart in Chapter 4 onward) while spawning coins.
- (Removed in Repentance) Each use pays out with 1-3 coins.
  - (Added in Repentance) Each use pays out with 1-2 coins on Normal mode or 1 coin on Hard mode.
- (Added in Afterbirth) Spawns 0-1 coins instead when used by (Keeper) Keeper.

(Added in Repentance) This item can be found when causing a (Blood Donation Machine.png) Blood Donation Machine to explode by donating Hearts to it.
If Isaac doesn't have the required Red Hearts or filled Bone Hearts, then Soul, Black, and empty Bone Hearts are taken instead.
This effect is counted as inflicted damage for items that spawn pickups upon said inflicted damage, such as Gimpy or Fanny Pack, but does not decrease the chance of encountering the (Devil Room) Devil Room / (Angel Room) Angel Room.
Invulnerability will not prevent Isaac from losing hearts.
(Removed in Repentance) Can be used before taking damage (getting hit, walking over spikes, donating to a (Blood Donation Machine.png) Blood Donation Machine, donating to a (Devil Beggar.png) Devil Beggar, going through a (Curse Room) Curse Room, etc.) to grant coins without inflicting extra damage.
(Added in Repentance) Does not allow Isaac to avoid damage taken by using a (Blood Donation Machine.png) Blood Donation Machine or (Devil Beggar.png) Devil Beggar.
Using this item as (The Lost) The Lost will kill him.
(Added in Repentance) Using this item in Mirrored World kills Isaac.

(Added in Repentance) Book of Virtues: Spawns wisps in the outer ring, resembling coins. The wisps only have one health.
(Removed in Repentance) Isaac's Heart: Can be used without taking damage, resulting in an infinite amount of coins.
- (Added in Afterbirth) Isaac still takes damage from this during The Guardian challenge.
(Removed in Repentance) PHD: Increases each payout by 0-2 coins.
- (Added in Repentance) PHD: IV Bag always pays out with 2 coins.
Portable Slot: Can be alternated between to gain ridiculous amounts of pickups from only a few initial coins or hearts.
(Removed in Repentance) Scapular: Allows for infinite coins once Isaac is at half a red heart (or full red heart in Chapter 4 onward) by moving between rooms to reset Scapular's effect.

(Added in Afterbirth) Car Battery: No effect.
(Added in Afterbirth) Holy Mantle and similar items: IV Bag ignores the shield's protection, resulting in Isaac taking damage regardless.