Large Zit 
Effects
- While firing, Isaac has a chance to fire an additional creep shot that deals double damage and leaves a short trail of white creep that slows enemies.
- The chance is not affected by luck.
- The creep shots don't take on any tear effects.
- (Removed in Repentance)The creep shots are affected by range and shot speed.
- (Added in Repentance)The creep shots are not affected by range but affected by shot speed, which determines their effective range.
- Their tear sizes are not affected by their damage. They always retain their small size.
- A creep shot will also be fired in a random direction when taking damage.
- Unlike most creep effects, this creep will affect flying enemies.
Synergies
Interactions
20/20 /
The Inner Eye /
Mutant Spider: Isaac will still fire one creep shot.
- (Added in Repentance)
Bird's Eye /
Ghost Pepper: Firing creep shots does not spawn the fires.
Compound Fracture /
Cricket's Body /
The Parasite: Creep shots will not burst into split tears.
Dead Eye: Creep shots do not grant or reset the damage multiplier, although their damage still benefit from the multiplier.
Eye of Belial: Creep shots are not affected.
Eye of Greed /
Lead Pencil: Creep shots are not counted for shots fired.
- (Added in Repentance)
Eye of the Occult: Creep shots are not controlled. Creep shots will only fire in cardinal or diagonal directions unless there is a cross-hair, in which case creep shots will fire directly toward it.
Incubus / (Added in Repentance)
Twisted Pair: The familiars does not fire creep shots.
- (Added in Repentance)
Immaculate Heart: Firing creep shots does not spawn the orbiting tear.
Lachryphagy: Creep shots are not affected from Lachryphagy, but Lachryphagy tears can feed on them.
The Ludovico Technique: Movable tear behaves as normal. Isaac will occasionally fire a creep shot while moving the tear, and creep shots will only fire in cardinal or diagonal directions.
A Lump of Coal: Creep shots are not affected.
My Reflection /
Tiny Planet /
Tractor Beam: Creep shots are not affected by the trajectory altering effect. Stat changes are applied as normal.
Pop!: Creep shots are not affected. Pop! tears do not bounce off of creep shots.
Proptosis: Creep shots are not affected.