Lost Soul

Effects

• Creates a ghostly familiar that closely follows behind Isaac. It dies in one hit, respawning at the start of the next floor.
• If Lost Soul survives until the start of the next floor, it rewards Isaac with one of the following:
  • 3 Soul Hearts.
  • 2 Eternal Hearts.
  • A Treasure Room item or an Angel Room item.

Notes

• Floors completed during the Ascent count.
• Waiting until after the floor is cleared before picking up Lost Soul nearly guarantees a reward payout on the next floor.
• The ghost can take explosive damage from Isaac, e.g. via placing a bomb.

Synergies

• BFFS!: Gives Lost Soul a once-per-room shield, similar to Holy Mantle.
  • If BFFS! is dropped, the shield will still remain active until taking one hit of damage, acting similarly to (Holy Card) Holy Card.
• Forget Me Now: Restarting a floor prompts Lost Soul to give a reward if it's alive when used.

Interactions

• Box of Friends: Cannot duplicate the ghost and won't spawn a Demon Baby, even when the ghost is dead.
• Bursting Sack / Skatole: Does not provide immunity to contact damage from spiders/flies to Lost Soul.
• (Child Leash) Child Leash: No effect.
• (Duct Tape) Duct Tape: No effect.
• Lost Soul: Picking up multiple Lost Souls has no effect, even if one died previously.