Angelic Prism 
Effects
- Spawns an orbital familiar with a large orbital radius. Tears that pass through the prism split into four multi-colored tears.
Notes
Synergies
- (Added in Repentance)
Akeldama: Turns the chain of tears into four multi-colored chains.
Anti-Gravity: Tears that are floating in the air when they hit the prism will quadruple but will not move. Tears that begin moving before they hit the prism will travel outwards normally.
- By releasing the built up tears as the prism passes by, significantly more tears can be affected than normal.
- (Duct Tape) Duct Tape: By keeping the prism in the same spot, damage output can be significantly increased in that direction.
- Duct Tape +
Incubus: By stacking the incubus familiar on top of the prism before picking up Duct Tape, the shots will be affected no matter what direction Isaac is firing.
- (Added in Repentance)
Immaculate Heart: The extra spectral tears share the same orbit as Angelic Prism, making them very easy to split.
Jacob's Ladder: All of the split tears will be electrified. Also, electric arcs that pass through the prism will be split.
The Ludovico Technique: While the tear is in contact with the prism, it will fire 4 additional tears in cardinal directions at Isaac's tear rate.- (Added in Repentance)
Saturnus: Since the prism and the orbiting tears have the exact same orbital radius, orbiting tears will immediately be split into 28 multi-colored tears upon entering a room.
- (Added in Repentance)
Sharp Key: Key projectiles can split thru the prism, leading to potentially massive damage.
Tractor Beam: Tears will split but continue stacked on top of each other along the tractor beam, essentially quadrupling the shot's damage.
Interactions
BFFS!: Only a visual size change, with no difference in the hitbox and thus usefulness of the Prism.
Brimstone / (Added in Repentance)
Revelation / 
Shoop Da Whoop! / 
Tech.5 / 
Technology / 
Technology 2: The laser is split in four.- (Added in Repentance)
C Section: Fetuses split in four.
- (Chaos Card) Chaos Card: Four cards are shot out if Chaos Card hits the prism.
- (Removed in Repentance)
Dr. Fetus: Split bombs can also damage charmed enemies summoned by Friendly Ball, Poke Go, and Delirious.
- (Removed in Repentance) Dr. Fetus +
Remote Detonator: Bombs split through the prism cannot be remotely detonated.
Epic Fetus: No effect.- (Added in Repentance)
Eraser: The Eraser splits, like normal tears.
- (Removed in Repentance)
Ipecac: Split explosions can also damage charmed enemies summoned by Friendly Ball, Poke Go, and Delirious.
Mom's Knife: When the knife touches the prism, split knives are launched that do not return to Isaac. The extra knives deal only 1x damage, unlike normal thrown knives.
My Reflection: Tears made by the prism will not quadruple once more if they hit the prism again.
Proptosis: Tears that hit the prism will continue to shrink as normal even after they split until they disappear.- (Added in Repentance)
Rocket in a Jar: Rockets do not split, unless its paired with Dr. Fetus, and even then only normal attacks are affected.
Rubber Cement: Tears will split and will bounce if they hit a wall. However, if split tears hit the prism, they will not split again.
Tech X: Laser rings are split into four.
Tiny Planet: Tears that hit the prism will quadruple, but all four tears will overlap and follow the same orbit.- (Added in Repentance)
Urn of Souls: The flames split into four multicolored flames.