Godhead 
Effects
Notes
- (Removed in Repentance) Godhead is a special item.
- The damaging aura gets bigger with items that make tears bigger, e.g.
Cricket's Head,
Polyphemus, and (Added in Afterbirth)
Pupula Duplex.
- (Removed in Repentance) The aura deals 30% of Isaac's damage 15 times per second.
- (Added in Repentance) The aura deals 2 damage 15 times per second.
Synergies
- (Added in Afterbirth †)
Compound Fracture/
Cricket's Body/
The Parasite: Main tears and burst tears retain all effects.
- (Added in Afterbirth)
Explosivo/(Added in Repentance)
Mucormycosis: Causes damaging aura to grow once attached to an enemy.
- (Added in Afterbirth †)
Euthanasia: Needles retain homing and damaging aura.
- (Added in Afterbirth)
Glass Cannon: The huge tear gains the homing ability and a much larger, more powerful damaging aura.
- (Added in Afterbirth †)
Lachryphagy: Fired tears and burst tears retain aura and homing effect.
- Piercing tears: When a tear bursts, the 8 smaller tears' auras can stack, doing massive damage to enemies within.
The Ludovico Technique: Tear increases in size and gains the damaging aura effect.
- (Added in Repentance) Tear also gains homing effect. May cause Tear to get stuck near enemies.
A Lump of Coal: The size and damage of the aura increases as long as the tear is on screen.
- (Pulse Worm) Pulse Worm: The aura increases and decreases in size.
- (Added in Repentance)
Saturnus: The orbiting tears also have the damaging aura, but without the homing effect.
Interactions
Brimstone: Brimstone laser retains the homing effect, but doesn't receive the damaging aura.
Dr. Fetus: Bombs retain the homing effect, but don't receive a damaging aura.
Epic Fetus: The crosshair homes in upon enemies, but neither the crosshair nor the missiles receive the damaging aura.
- (Added in Afterbirth †)
Haemolacria: Main tear retains all effects, but burst tears do not.
- (Added in Repentance) Burst tears also retain all effects.
Mom's Knife: Knife retains the homing effect, but doesn't get the damaging aura.
- Piercing tears: Once the tear hits the enemy, the aura also ceases to do damage to that particular target.
- (Added in Repentance) Enemies can be damaged by the aura after being pierced, but only if the tear is no longer in contact.
- (Added in Afterbirth †)
Sinus Infection: The aura on booger tears stuck to an enemy won't hurt that particular enemy, but still damages other enemies.
Technology/
Technology 2/
Tech.5/(Added in Afterbirth)
Tech X: Lasers retain the homing effect, but don't receive the damaging aura.
- (Added in Afterbirth †)
Trisagion: Causes Godhead's aura to visually disappear; however, the aura is still there and can still damage enemies.
- (Added in Repentance) The aura is invisible and extremely small. It is unlikely to get any meaningful extra damage from it.