Monster Manual

Effects

When used, a random familiar will be spawned from the following:

• ???'s Only Friend

• (Added in Afterbirth †) Angry Fly

• Ball of Bandages

• (Added in Repentance) BBF

• (Added in Repentance) Big Chubby

• Big Fan

• (Added in Repentance) Bloodshot Eye

• Bob's Brain

• (Added in Repentance) Boiled Baby

• (Added in Repentance) Bot Fly

• Brother Bobby

• Cube of Meat

• Demon Baby

• Distant Admiration

• Dry Baby

• (Added in Repentance) Farting Baby

• (Added in Repentance) Fate's Reward

• Forever Alone

• (Added in Repentance) Freezer Baby

• (Added in Repentance) Friend Zone

• (Added in Repentance) Fruity Plum

• (Removed in Repentance) Gemini

• Guardian Angel

• Halo of Flies

• Headless Baby

• (Added in Repentance) Hushy

• (Added in Repentance) Incubus

• Juicy Sack

• Leech

• (Added in Repentance) Lil Abaddon

• Lil Brimstone

• (Added in Repentance) Lil Delirium

• (Added in Repentance) Lil Gurdy

• Lil Haunt

• (Added in Repentance) Lil Loki

• (Added in Repentance) Lil Monstro

• (Added in Repentance) Lil Spewer

• Little Chubby

• Little Gish

• Little Steven

• (Added in Repentance) Lost Fly

• (Added in Repentance) The Peeper

• Robo-Baby

• Robo-Baby 2.0

• Rotten Baby

• (Added in Repentance) Seraphim

• (Added in Repentance) Shade

• Sissy Longlegs

• Sister Maggy

• Smart Fly

• (Added in Repentance) Succubus

• (Added in Repentance) Sworn Protector

• (Added in Repentance) Tinytoma

• (Added in Repentance) Twisted Pair

• (Removed in Repentance) Familiars spawned by Monster Manual last for the current room.

  • (Added in Repentance) Familiars spawned by Monster Manual last for the rest of the floor.

• Familiars generated by Monster Manual do not contribute toward transformations.

• (Added in Afterbirth †) This item belongs to the Bookworm set. Collecting three items from this set will transform Isaac into Bookworm.

Notes

• It can spawn familiars not yet unlocked.
• If Cube of Meat or Ball of Bandages are spawned and Isaac already has either of those items, the level of these items will increase for the current (Removed in Repentance) room (Added in Repentance) floor.
• Using Monster Manual is a good method to unlock achievements related to Super Meat Boy and Super Bandage Girl.
  • Using Monster Manual and enough (Lil' Battery) Lil' Batterys, Super Meat Boy and Super Bandage Girl can both be achieved in the same run.
  • If Isaac does not already have the Cube of Meat or Ball of Bandages, Monster Manual can spawn a level 2 Cube of Meat or Ball of Bandages in one use.
• Mongo Baby will not copy familiars spawned by Monster Manual.
• Familiars spawned by Monster Manual cannot be rerolled into other items by D4 or D100.
• (Added in Afterbirth) Box of Friends will not duplicate familiars spawned by Monster Manual.
• (Added in Repentance) Tinytoma orbitals will persist between floors until they are all destroyed. They will not respawn outside of the floor they were generated in.
• (Added in Repentance) The familiars summoned by Monster Manual are items with a [monstermanual](/wiki/Item_Tags_monstermanual "Item Tags monstermanual") item tag.

Synergies

• (Added in Repentance) Book of Virtues: Spawns wisps in the inner ring. The given wisps function similarly to familiars given by Buddy in a Box.

Interactions

• (Added in Repentance) Sacrificial Altar: Summoned familiars can be sacrificed since they persist for the entire floor, even if Monster Manual isn't currently being held.